I've been on Trikafta for about 11 months now. It has radically changed my life. I am not "done" with CF, but I feel closer to being "cured" of this affliction than I ever thought possible. My gratitude to those who developed this drug is vast and inexpressible. I may live several decades longer. The price tag is unreasonable (about 30 times more than I make in a year) but thank the gods my insurance pays for it! I fervently hope that all qualifying CFers everywhere in the world can gain access to this drug. I do less than half of the breathing treatments I used to and my lung function has gone up about 10%. I no longer rely on antibiotics anymore - I've only had them twice since starting Trikafta (once using IV antibiotics during the "flu-like thing" described below, and once with oral abx in May). I have a taste of what it feels like to be "normal"!