Since about 2013, a portion of the CF community has been experimenting with "the Combo", or the combination of curcumin plus genistein supplements to help modulate CFTR function. This intervention is proving to be very helpful for many people who try it, yet we're still in the beginning stages of our experimentation. The impacts of the Combo are somewhat mutation-specific, and the rate of digestive absorption of these herbs varies person to person, thus the dose must be deduced via personal experimentation.
The Combo is a simple and safe intervention with few side effects and is relatively cheap (compared to pharmaceutical CFTR modulators like Kalydeco, which cost $300,000 a year!). Both of these supplements are made up of plant constituents (genistein from soy and curcumin from turmeric root), and as you know, I'm an herbalist and a believer in the healing power of plants.
Mica McDonald (they/he) is a clinical herbalist, nutritionist, ecologist, and writer living in Abenaki territory (Vermont).